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Gambit traveled to New York to find Sinister before the Thieves Guild could on the orders of Candra, who hoped to learn about Apocalypse from Sinister himself.
In exchange for the lives of the Thieves' Guild members who got caught by Sinister, Gambit traded in a sample from Courier to Sinister in exchange for the information which was given to the now freed Guild's members who went off to find Apocalypse's hidden sanctuary protected by Ozymandias.
In 1899 in England, Sinister helped awaken Apocalypse from his slumber.
He developed advanced theories on human evolution and was obsessed with Charles Darwin’s theory of evolution, though he felt Darwin and his contemporaries were shackled by too many moral constraints and that science was beyond morality. Essex dreamed of bringing the perfection of the evolution of the human race to the masses. Essex's son, Adam Essex's, death at the age of four from numerous birth defects, including crooked bones and hemophilia, Dr. After awaking, the immortal mutant, En Sabah Nur, ordered the Marauders to take him to Dr. Essex was necessary for the birth of Nathan Dayspring, the Askani'son, who Madame Sanctity worshipped. Essex even went so far as to dig up his dead son and experiment on him.
Essex and the time-travelers, Cyclops and Phoenix, arrived, believing that they were to prevent Dr. Sinister, but unaware that Madame Sanctity of the Clan Askani had sent them to the past to stop Nur from conquering England. Growing more curious of her husband's work, Rebecca Essex checked in Dr.
Essex's lab, to find the body of their son in an incubation tube. Essex explained to Nur that he was the first born in, what Dr.
After digging-up Adam's grave to prove her suspicions, Rebecca passed-out, from the shock of finding the coffin empty, and Nur approached Dr. Left with the choice of continuing his work or his wife shunning him, Dr. Essex believed, would be a great mutation in the human race.