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The neurons that give rise to nerves do not lie entirely within the nerves themselves—their cell bodies reside within the brain, spinal cord, or peripheral ganglia Glial cells (named from the Greek for "glue") are non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.

In insects, many neurons have cell bodies that are positioned at the edge of the brain and are electrically passive—the cell bodies serve only to provide metabolic support and do not participate in signalling.A protoplasmic fiber runs from the cell body and branches profusely, with some parts transmitting signals and other parts receiving signals.Thus, most parts of the insect brain have passive cell bodies arranged around the periphery, while the neural signal processing takes place in a tangle of protoplasmic fibers called neuropil, in the interior.White matter includes all of the nerves, and much of the interior of the brain and spinal cord.Grey matter is found in clusters of neurons in the brain and spinal cord, and in cortical layers that line their surfaces.

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